Spotlight
AI Chat Platform Lets Epilepsy Patients Query Their Brain Data and Cuts False Seizure Alarms
·Pepkio Team·3 min read
In a prospective, single-center observational study reported in Nature Medicine, researchers led by Brian Litt at the University of Pennsylvania, with first author Zack Goldblum, tested a platform that links scalp or…
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Multiview AI model reads whole coronary angiograms, predicts 1-year cardiac events
·Pepkio Team·4 min read
A vision-language model trained on more than 200,000 coronary angiography videos can interpret an entire angiographic study — not just a single frame or projection — and use those videos alone to estimate a patient's…
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Invisible watermarks for AI-designed proteins preserve their function
·Pepkio Team·3 min read
Google DeepMind researchers report today in Nature a new toolkit, SynthIDBio, that can watermark AI-generated protein sequences and structures without breaking their biological activity. The work, led by senior author…
Read summary →AI-guided formulation stabilizes mRNA vaccines for months at body temperature
·Pepkio Team·3 min read
An AI-guided approach has identified solid-state formulations that keep messenger RNA (mRNA) vaccines active for months at 37 °C, potentially removing the ultracold storage barrier that limits global vaccine…
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Hippocampal neurons encode word meanings through distributed, LLM-like population codes
·Pepkio Team·2 min read
The human hippocampus represents word meanings not through single “concept cells” but through distributed patterns of activity across many neurons—a coding scheme that mirrors the semantic geometry of large language…
Read summary →AI maps cell-level signatures of Alzheimer’s disease phenotypes in millions of brain nuclei
·Pepkio Team·2 min read
An artificial intelligence framework has sifted through more than 6 million single-cell transcriptomes from human prefrontal cortex to pinpoint the specific cell subpopulations, genes, and pathways that may underlie…
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Multi-agent AI platform mines thousands of clinical trials to pinpoint features of successful drug targets
·Pepkio Team·3 min read
Scientists report today in Science a multi-agent artificial intelligence system that can analyze and integrate biomedical data across scales to inform drug development decisions. The work, led by senior author James Zou…
Read summary →Paper2Agent turns static scientific papers into interactive, reliable AI agents
·Pepkio Team·3 min read
Scientists report in Nature a new system, Paper2Agent, that automatically converts research papers into interactive AI agents—so that instead of reading code, installing dependencies, and manually reconstructing…
Read summary →Small, specialized AI models outshine trillion-parameter giants on new aging biology benchmark
·Pepkio Team·3 min read
A new open benchmark reveals that even the most advanced large language models (LLMs) struggle to interpret raw molecular data from aging studies—but compact, fine-tuned models as small as 0.6 billion parameters can…
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New platform enables ultrafast, reference-free sequence searches across millions of single cells
·Pepkio Team·3 min read
Scientists report today in Nature the launch of Malva, a computational platform that allows researchers to search for any RNA sequence – from viral genomes to cancer mutations – across millions of single cells in…
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New AI model predicts how cells respond to drugs and genetic perturbations across diverse contexts
·Pepkio Team·2 min read
Scientists at the Arc Institute have developed State, a machine learning model that predicts how individual cells will respond to drugs, genetic edits, and other perturbations—even in cell types or tissues where no such…
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FuncVEP: functional training yields best-performing missense variant predictor, uncovers new disease links
·Pepkio Team·2 min read
A new family of variant effect predictors, FuncVEP, trained exclusively on experimental functional data rather than clinical labels, outperforms 48 existing tools across multiple benchmarks, scientists report today in…
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Deep learning unlocks de novo design of complex RNA pseudoknots
·Pepkio Team·2 min read
Complex RNA structures govern fundamental processes like translation and viral replication, but designing entirely new RNA folds from scratch has remained out of reach—until now. Scientists report today in Science that…
Read summary →AI-designed cell-surface tags boost antigen display for vaccines and CAR-T therapies
·Pepkio Team·2 min read
Scientists report today in Nature Biotechnology that a deep learning suite called DeepSCan can discover and design potent cell-surface display (CSD) elements — short protein modules that anchor antigens or receptors to…
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AI that learns the mechanics of prime editing picks better guides—and fixes a mutation in mouse brains
·Pepkio Team·3 min read
Prime editing can rewrite DNA with great precision, but finding the right guide RNA often means testing hundreds of candidates. A new machine-learning tool, OptiPrime, cuts that search down dramatically—and, in a mouse…
Read summary →Aligning protein AI with experimental fitness stabilizes influenza vaccines
·Pepkio Team·2 min read
Scientists report today in Nature Methods a new way to make protein-generating AI models follow experimental fitness data. The work, led by Brian L. Hie at Stanford University, with first author Talal Widatalla,…
Read summary →AI model PRISM2 matches clinical-grade pathology tests without additional training
·Pepkio Team·2 min read
Scientists report today in Nature Medicine that a new AI model, PRISM2, trained on millions of pathology images and clinical reports, can detect cancer in prostate, breast, and lymph node samples with accuracy matching…
Read summary →AI tool 'Raygun' shrinks and expands proteins while preserving function, opening new avenues for protein engineering
·Pepkio Team·3 min read
Scientists report recently in Nature a new AI framework called Raygun that can miniaturize, expand, and modify natural proteins while preserving their function. The work, led by senior author Rohit Singh at Duke…
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A Smaller AI Model Learns How Proteins Interact, Challenging the Need for Massive Protein Language Models
·Pepkio Team·2 min read
Understanding how proteins interact is crucial for decoding cellular functions and developing targeted therapeutics. However, current AI models struggle to predict these complex interactions without relying on massive,…
Read summary →Generalist AI Agent Matches Experts on Biomedical Research Tasks While Slashing Analysis Time
·Pepkio Team·3 min read
Biomedical research is often bogged down by fragmented, time-consuming workflows that require stitching together specialized tools, vast datasets, and deep domain knowledge. A study published today in Science describes…
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